HGH Up by Applied Nutriceuticals
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SUPPORT INCREASES IN GH LEVELS!
What is HGH UP and What Does it Do?
HGH UP® is the worldâÌÎå«ÌÎÌíëí_íë_íëÇí«ííëí_í«íëÇí«ÌÎå«Ì´åÈs first ÌÎå«ÌÎÌ¥Hybrid Anabolic/Near HormonalÌÎå«ÌÎÌÕ product.* In other words, itâÌÎå«ÌÎÌíëí_íë_íëÇí«ííëí_í«íëÇí«ÌÎå«Ì´åÈs able to support physiological benefits while minimizing potential side effects and disruption of endogenous hormone levels post-usage.*
The Basics of HGH UP
Helps support a healthy level of somatostatin; a hormone that limits Growth Hormone production*
Promotes serum HGH production in the pituitary*
Supports the output of growth hormone and local IGF-1 levels*
What Makes HGH UP the Most
Effective GH Booster on the Market?
Over the last 20 years, a variety of products that claim to boost HGH orally have been promoted in the US sports supplement market. The vast majority of these products have been completely ineffective for several reasons:
Growth hormone is a peptide (a long chain amino acid structure), that cannot be taken in an oral form, due to the destruction of the sequence by the acidic environment of the stomach. Any supplement containing ÌÎå«ÌÎÌ¥oral growth hormoneÌÎå«ÌÎÌÕ is a scam. (47)
Many products use a combination of amino acids such as arginine and lysine in ÌÎå«ÌÎÌ¥kitchen sinkÌÎå«ÌÎÌÕ formulas, and claim that their combination is ÌÎå«ÌÎÌ¥scientifically provenÌÎå«ÌÎÌÕ to work. Many amino acids boost growth hormone levels, but most of the time, it is only when taken in completely unattainable dosages that would make a normal person extremely sick. And the correct dosage is in gram amounts, not in the milligram range offered in many of these products. (41-47)
Even if these products allow for a viable release of GH, there is nothing present to inhibit somatostatin, which has been found to be the biggest factor in controlling GH levels. (9-15)
Many of these products are powdered mixes that contain sugar, sweeteners, or other compounds that may increase blood sugar. As discussed above, this will render the product virtually useless due to the inverse relationship between glucose and growth hormone.
HGH UPâÌÎå«Ì´åÈÌÎå«ÌÎå¢ differs from these compounds because of the nature of the formulation. Every compound in the product is designed to work in concert with the other components; no filler or ineffective components are found in this product.
HGH UPâÌÎå«Ì´åÈÌÎå«ÌÎå¢ utilizes the latest research on compounds which have been overlooked by other companies. The secret of the product is in the complexity, effectiveness and synergism of the blend.
HGH UPâÌÎå«Ì´åÈÌÎå«ÌÎå¢ is the first product to positively manipulate somatostatin; this alone puts it in a class by itself.* (9-15)
HGH UPâÌÎå«Ì´åÈÌÎå«ÌÎå¢ also utilizes components that boost androgen levels, support the number and function of androgen receptors, and promote an overall anabolic environment in which levels of testosterone and GH are optimized.* (24-27)
MUCUNA PRURIENS, VITAMIN B6 & L-DOPA
Support Growth Hormone Output and Testosterone Production While Concurrently Decreasing Somatostatin and Prolactin.*
HGH UPâÌÎå«Ì´åÈÌÎå«ÌÎå¢ contains highly concentrated L-Dopa derived from Mucuna Pruriens. Mucuna Pruriens is an Ayurvedic Herb that has L-Dopa-increasing qualities (32). L-Dopa has been suggested to support levels of growth hormone in human subjects when administered orally.* (1-3,33)
Oral viability in HGH UPâÌÎå«Ì´åÈÌÎå«ÌÎå¢ critical for product effectiveness, as growth hormone cannot be absorbed and is rendered ineffective due to the fragility of the ingredients. Several good examples are synthetic growth hormone and growth hormone releasing hormone. These compounds cannot be administered orally; because of their fragile amino acid sequence is destroyed by stomach acids. This also holds true with the vast majority of the so-called ÌÎå«ÌÎÌ¥GH BoostersÌÎå«ÌÎÌÕ and ÌÎå«ÌÎÌ¥PeptidesÌÎå«ÌÎÌÕ commonly found in sports nutrition products.
L-Dopa and Dopamine have also been suggested to help reduce prolactin, a hormone that suppresses male testosterone production. Prolactin also has a positive correlation with a second hormone called somatostatin, which decreases the amount and effectiveness of circulating growth hormone. Therefore, by lowering prolactin (and consequently somatostatin) levels, HGH UPâÌÎå«Ì´åÈÌÎå«ÌÎå¢ supports both testosterone and GH production.* (38-39).
Vitamin B6 is also included in the formula for HGH UPâÌÎå«Ì´åÈÌÎå«ÌÎå¢, as it can also help promote healthy prolactin levels and support the night-time peak of GH release pulse, while at the same time increasing the rise in GH associated with exercise by as much as 23%.* (7)
Increasing AChE Inhibition and
Mean serum GH by Decreasing Somatostatin*
Huperzine-A is a strong acetylcholine esterase (AChE) inhibitor. Acetylcholine esterase inhibitors have been suggested in numerous scientific studies to inhibit somatostatin via a variety of synergistic biomechanisms; all of which contribute to increased levels of growth hormone.* (9-18)
Somatostatin is a hormone that exerts effects on anterior pituitary as well as pancreatic, liver and gastrointestinal function. (40-43)
Somatostatin is of extreme importance because it directly effects growth hormone release and is a major regulating factor in growth hormone output.
By inhibiting somatostatin, overall mean serum GH may increase.* (41-42)
Somatostatin inhibits GH secretion indirectly via antagonizing GHRH secretion (41-43).
Consequently, the Huperzine-A, in HGHUPâÌÎå«Ì´åÈÌÎå«ÌÎå¢ increases the length, intensity, duration of growth hormone pulses and supports mean serum GH levels.*(8,10,12-17,19-20)
GREEN TEA EXTRACT & EGCG
Supports Dopa Decarboxylase Inhibition and the
AChE-inhibiting Effects of HGH UPâÌÎå«Ì´åÈÌÎå«ÌÎå¢
Dopamine crosses the blood/brain barrier poorly, and cannot exert optimal effects on target receptors unless enough of the compound reaches the brain. L-Dopa is freely absorbed across this barrier, and when L-dopa crosses the barrier readily, growth hormone levels increase.* (1-6,32-33)
L-Dopa is most effective when conversion of L-Dopa to dopamine is mediated by a decarboxylase inhibitor. A decarboxylase inhibitor is a substrate that inhibits the metabolism of one biological entity into another biological entity. (2-5,19-20,37)
A decarboxylase inhibitor is generally administered at the same time as L-Dopa / Mucuna in order to reduce conversion of the L-dopa into dopamine in the periphery. (âÌÎå«ÌÎå_ÌÎå«ÌÎå´)-epigallocatechin-3-O-gallate (EGCG), which is found in high amounts in the green tea extract used in HGH UPâÌÎå«Ì´åÈÌÎå«ÌÎå¢, is a possible decarboxylase inhibitor.*The decarboxylase-reducing qualities of EGCG have been suggested by several recent studies, in that EGCG seems to prevent L-dopa from converting into dopamine; allowing more significant levels of L-dopa to reach the brain and support growth hormone levels.* (1-5,37)
EGCG has also been suggested to increase the effects of Huperzine A on acetylcholine esterase inhibition by increasing the transport of Huperzine-A by serum albumin. This allows for greater amounts of acetylcholine to be present, therefore allowing for greater mean serum growth hormone.* (19-20)
L-CARNITINE-L-TARTRATE & MAGNESIUM
Increasing Androgen Receptor Number and Density, and the
Creation of a Better Binding Environment!
L-Carnitine L-Tartrate is an amino acid that has been suggested to increase the number of androgen receptors in skeletal muscle, creating a better binding environment for testosterone and other androgens by allowing for a greater number of intact receptors available for hormonal interactions.*(21-23)
Magnesium has been suggested by more recent studies to inhibit the binding of steroid hormone binding globulin (SHBG) and free testosterone.* SHBG binds free testosterone and allows it to be excreted from the body, without binding the androgen receptor. Magnesium keeps this from happening by altering the binding affinity of testosterone to SHBG; which may allow for increased amounts of free testosterone to remain active in the bloodstream.*(24)
Other human research suggests that supplemental magnesium, when taken along with other ingredients like DHEA and Zinc, can significantly increase free testosterone.*(25-27)
Therefore, HGH UPâÌÎå«Ì´åÈÌÎå«ÌÎå¢ allows for greater numbers of androgen receptors and a better binding environment for testosterone in skeletal muscle.* This is a new breakthrough in sports supplementation as HGH UPâÌÎå«Ì´åÈÌÎå«ÌÎå¢ creates a better target for circulating free testosterone, allowing for greater binding of testosterone to the extra receptors which leads to increased protein synthesis, better recovery, and increased muscle mass.*
MUCUNA PRURIENS & CHLOROPHYTUM BORIVILLANUM
Increasing Testosterone Levels!
Mucuna Pruriens has been suggested in several recent human studies to support testosterone levels in animal studies and humans, via prolactin inhibition.* Prolactin, as mentioned earlier, is a hormone that suppresses male testosterone production. (30-31,34-36, 38-39).
The ethanolic and sapogenic extracts of Chlorophytum Borivaillanum have also been suggested in animal studies to support testosterone, and anecdotal data from products containing this compound also point to supporting testosterone and lean body mass for users of this phyto-androgenic compound.* However, the mechanism of action of Chlorophytum is poorly understood. (28- 29)
DonâÌÎå«ÌÎÌíëí_íë_íëÇí«ííëí_í«íëÇí«ÌÎå«Ì´åÈt Believe Us? We have the science to back it up!
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